![](https://static.wixstatic.com/media/e1272c_1e97d6e96bfd4bc6b1eab4caf983a107~mv2.jpg/v1/fill/w_1920,h_1080,al_c,q_90,enc_auto/e1272c_1e97d6e96bfd4bc6b1eab4caf983a107~mv2.jpg)
Joshua Harris
Rising Biomedical Engineer
![JoshHarris_LabPhoto.jpg](https://static.wixstatic.com/media/e1272c_4b5a7b7bd9034ac49ce52ec05ef408a0~mv2.jpg/v1/crop/x_53,y_0,w_407,h_512/fill/w_284,h_360,al_c,q_80,usm_0.66_1.00_0.01,enc_auto/JoshHarris_LabPhoto.jpg)
![](https://static.wixstatic.com/media/e1272c_1e97d6e96bfd4bc6b1eab4caf983a107~mv2.jpg/v1/fill/w_980,h_551,al_c,q_85,usm_0.66_1.00_0.01,enc_auto/e1272c_1e97d6e96bfd4bc6b1eab4caf983a107~mv2.jpg)
Image Analyst --- Currently writing a Manuscript May 2017-Aug 2020
Neuroengineering Rehabilitation and Degeneration (NERD) Lab
NEC 350, Wright State University, Dayton, OH
Lab Website 937-775-2493
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Physics II / Anatomy and Physiology I Tutor Aug-Dec 2016
Academic Success Center
Wright State University, Dayton, OH
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Anatomy and Physiology I Lab Teaching Assistant Jan-Apr 2016
Boonshoft School of Medicine
Wright State University, Dayton, OH
Thesis: Kv2.1 Channel Clustering in the SOD1-G93A Mouse Model of ALS August 2020
-In the NERD lab, our work revolves around the investigation of Amyotrophic Lateral Sclerosis, or ALS. This is a neurodegenerative disease which kills motoneurons (spinal cord cells), degrades muscle, and ultimately is fatal. For my thesis, I investigated the morphological changes of Kv2.1 channels. These channels work in conjunction with other ion channels to regulate cell function in the spinal cord. Using immunohistochemical techniques, I sought to understand more about how these channels change and compensate for the disease throughout its progression. To examine these channels in detail, I collected data from the SOD1-G93A mouse model at four different time points: post-natal day (P)10, P30, P90, and End Stage (ES: P120-140).
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Manuscript: Contrasting changes in Kv2.1 channel expression level between Publication Expected
disease-resistant and disease-vulnerable SOD1-G93A motoneurons in ALS Mid 2021
-This manuscript is the first step in my thesis. Using the mouse model and its time points outlined above, I am currently investigating the Kv2.1 channel throughout disease progression. Kv2.1 channels are also known as delayed rectifier channels, and they serve to regulate motoneuron excitability through the efflux of Potassium. Considering their role in motoneuron homeostasis, any change under ALS pathogenesis would be interesting to explore and investigate.
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